Assay Detail
Binding
CHEMBL702801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of L-type Ca+2 channels
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095229) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.43 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20896 | — | — | 1 | 5.57 |
| CHEMBL102826 | — | — | 1 | 5.28 |
| CHEMBL319593 | — | — | 1 | - |
| CHEMBL322693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20896 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL102826 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL319593 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322693 | — | IC50 | > | 10000.0 | nM | - |