Assay Detail
Functional
CHEMBL702816
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In vitro inhibition of K-562 cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552873 | — | — | 1 | 7.40 |
| CHEMBL554551 | — | — | 1 | 6.16 |
| CHEMBL282988 | — | — | 1 | 6.00 |
| CHEMBL300580 | — | — | 1 | 5.82 |
| CHEMBL553022 | — | — | 1 | 5.22 |
| CHEMBL3216873 | — | — | 1 | 4.92 |
| CHEMBL554203 | — | — | 1 | 4.92 |
| CHEMBL554057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552873 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL554551 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL282988 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL300580 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL553022 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3216873 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL554203 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL554057 | — | IC50 | > | 100000.0 | nM | - |