Assay Detail
Functional
CHEMBL702819
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In vitro cytotoxic activity required to inhibit human chronic myelogenous leukemia K-562 cell line
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.98 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148361 | — | — | 1 | 6.05 |
| CHEMBL423394 | — | — | 1 | 6.00 |
| CHEMBL356033 | — | — | 1 | 5.72 |
| CHEMBL145811 | — | — | 1 | 5.70 |
| CHEMBL358165 | — | — | 1 | 5.70 |
| CHEMBL150008 | — | — | 1 | 5.64 |
| CHEMBL148690 | — | — | 1 | 5.60 |
| CHEMBL146303 | — | — | 1 | 5.44 |
| CHEMBL149179 | — | — | 1 | 5.42 |
| CHEMBL435623 | — | — | 1 | 5.30 |
| CHEMBL423213 | — | — | 1 | 5.29 |
| CHEMBL149175 | — | — | 1 | 5.26 |
| CHEMBL357489 | — | — | 1 | 5.21 |
| CHEMBL146268 | — | — | 1 | 5.19 |
| CHEMBL146242 | — | — | 1 | 4.72 |
| CHEMBL358809 | — | — | 1 | 4.72 |
| CHEMBL149176 | — | — | 1 | 4.72 |
| CHEMBL344111 | — | — | 1 | 4.58 |
| CHEMBL146613 | — | — | 1 | 4.57 |
| CHEMBL148438 | — | — | 1 | 4.55 |
| CHEMBL434698 | — | — | 1 | 4.55 |
| CHEMBL356185 | — | — | 1 | 4.51 |
| CHEMBL149267 | — | — | 1 | 4.48 |
| CHEMBL148563 | — | — | 1 | 4.47 |
| CHEMBL150060 | — | — | 1 | 4.37 |
| CHEMBL149180 | — | — | 1 | 4.33 |
| CHEMBL146600 | — | — | 1 | 4.20 |
| CHEMBL149503 | — | — | 1 | 4.20 |
| CHEMBL146586 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148361 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL423394 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL356033 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL145811 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358165 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL150008 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL148690 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL146303 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL149179 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL435623 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL423213 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL149175 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL357489 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL146268 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL146242 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL358809 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL149176 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL344111 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL146613 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL148438 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL434698 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL356185 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL149267 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL148563 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL150060 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL149180 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL146600 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL149503 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL146586 | — | IC50 | = | 91000.0 | nM | 4.04 |