Assay Detail
Functional
CHEMBL702822
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In vitro inhibitory activity against K-562 cell line proliferation
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.63 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310136 | — | — | 1 | 7.30 |
| CHEMBL72618 | — | — | 1 | 7.30 |
| CHEMBL311379 | — | — | 1 | 7.22 |
| CHEMBL73376 | — | — | 1 | 7.22 |
| CHEMBL74549 | — | — | 1 | 7.16 |
| CHEMBL77883 | — | — | 1 | 7.16 |
| CHEMBL74548 | — | — | 1 | 7.16 |
| CHEMBL422414 | — | — | 1 | 6.85 |
| CHEMBL75889 | — | — | 1 | 6.82 |
| CHEMBL306107 | — | — | 1 | 6.82 |
| CHEMBL424605 | — | — | 1 | 6.82 |
| CHEMBL75167 | — | — | 1 | 6.75 |
| CHEMBL74932 | — | — | 1 | 6.70 |
| CHEMBL305688 | — | — | 1 | 6.70 |
| CHEMBL73947 | — | — | 1 | 6.60 |
| CHEMBL76274 | — | — | 1 | 6.60 |
| CHEMBL309911 | — | — | 1 | 6.58 |
| CHEMBL74931 | — | — | 1 | 6.46 |
| CHEMBL73912 | — | — | 1 | 6.35 |
| CHEMBL73574 | — | — | 1 | 6.16 |
| CHEMBL75561 | — | — | 1 | 6.12 |
| CHEMBL309753 | — | — | 1 | 5.52 |
| CHEMBL74188 | — | — | 1 | 5.52 |
| CHEMBL72202 | — | — | 1 | 5.26 |
| CHEMBL74492 | — | — | 1 | - |
| CHEMBL74708 | — | — | 1 | - |
| CHEMBL77790 | — | — | 1 | - |
| CHEMBL75170 | — | — | 1 | - |
| CHEMBL75522 | — | — | 1 | - |
| CHEMBL307716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310136 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL72618 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL73376 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL311379 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL74549 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL77883 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL74548 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL422414 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL424605 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL306107 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL75889 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL75167 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL74932 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL305688 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL76274 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL73947 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL309911 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL74931 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL73912 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL73574 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL75561 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL309753 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL74188 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL72202 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL308945 | — | IC50 | < | 12.0 | nM | - |
| CHEMBL308275 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL72992 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL75132 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL305915 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL75467 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL75714 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL307716 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL75522 | — | IC50 | < | 12.0 | nM | - |
| CHEMBL75170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL77790 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL74708 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL74492 | — | IC50 | < | 100.0 | nM | - |