Assay Detail
Binding
CHEMBL702866
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Tested for the affinity for the Ionotropic glutamate receptor kainate using [3H]kainate as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic kainate (CHEMBL2109241) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
N-sulfonyl derivatives of 6,7-dichloro 3,4-dihydro-3-oxo-quinoxalinecarboxylate as glycine-site NMDA and AMPA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.96 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155265 | DNQX | — | 1 | 5.54 |
| CHEMBL222519 | NBQX | — | 1 | 5.10 |
| CHEMBL126035 | — | — | 1 | 4.71 |
| CHEMBL130213 | 6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID | — | 1 | 4.49 |
| CHEMBL167548 | — | — | 1 | - |
| CHEMBL50267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155265 | DNQX | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL222519 | NBQX | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL126035 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL130213 | 6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL167548 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL50267 | — | IC50 | > | 100000.0 | nM | - |