Assay Detail
Functional
CHEMBL702940
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Compound was tested for its inhibitory concentration to inhibit the growth of wild type L1210 cells.
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48044 | — | — | 2 | 8.70 |
| CHEMBL46140 | — | — | 2 | 8.30 |
| CHEMBL416261 | — | — | 2 | 7.47 |
| CHEMBL44697 | — | — | 1 | 6.92 |
| CHEMBL45572 | — | — | 2 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48044 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL48044 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL46140 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL46140 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL416261 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL416261 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL44697 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL45572 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL45572 | — | IC50 | = | 680.0 | nM | 6.17 |