Assay Detail
Functional
CHEMBL702961
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Compound was tested for the inhibition of L1210 cell growth in mouse.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.09 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60700 | — | — | 1 | 6.75 |
| CHEMBL301895 | — | — | 1 | 6.66 |
| CHEMBL293148 | — | — | 1 | 6.52 |
| CHEMBL58548 | — | — | 1 | 6.38 |
| CHEMBL57549 | — | — | 1 | 6.36 |
| CHEMBL55437 | — | — | 1 | 6.31 |
| CHEMBL59261 | — | — | 1 | 6.19 |
| CHEMBL61300 | — | — | 1 | 5.82 |
| CHEMBL57269 | — | — | 1 | 5.72 |
| CHEMBL412127 | — | — | 1 | 5.57 |
| CHEMBL299062 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60700 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL301895 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL293148 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL58548 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL57549 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL55437 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL59261 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL61300 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL57269 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL412127 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL299062 | — | IC50 | = | 19000.0 | nM | 4.72 |