Assay Detail
Binding
CHEMBL703066
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Binding affinity towards Kai-2 using [3]H-kainate as the radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 5 (CHEMBL2675) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.96 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12465 | — | — | 1 | 5.01 |
| CHEMBL293613 | — | — | 1 | 4.96 |
| CHEMBL13076 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12465 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL293613 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL13076 | — | Ki | = | 12000.0 | nM | 4.92 |