Assay Detail
Functional
CHEMBL703318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to inhibit cell growth was determined against L1210 cell line of murine lymphocytotic leukemia
41
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antimitotic antitumor agents: synthesis, structure-activity relationships, and biological characterization of N-aryl-N'-(2-chloroethyl)ureas as new selective alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159826 | — | — | 2 | 7.16 |
| CHEMBL356033 | — | — | 1 | 5.92 |
| CHEMBL358165 | — | — | 1 | 5.89 |
| CHEMBL159697 | — | — | 1 | 5.57 |
| CHEMBL146303 | — | — | 1 | 5.52 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 5.52 |
| CHEMBL148690 | — | — | 1 | 5.52 |
| CHEMBL357489 | — | — | 1 | 5.42 |
| CHEMBL160114 | — | — | 1 | 5.42 |
| CHEMBL146268 | — | — | 1 | 5.37 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 5.35 |
| CHEMBL159887 | — | — | 1 | 5.30 |
| CHEMBL149175 | — | — | 1 | 5.30 |
| CHEMBL349708 | — | — | 1 | 5.27 |
| CHEMBL164268 | — | — | 1 | 5.27 |
| CHEMBL346689 | — | — | 1 | 5.22 |
| CHEMBL161784 | — | — | 1 | 5.09 |
| CHEMBL159809 | — | — | 1 | 5.06 |
| CHEMBL161374 | — | — | 1 | 5.05 |
| CHEMBL348741 | — | — | 1 | 5.02 |
| CHEMBL161012 | — | — | 1 | 4.96 |
| CHEMBL353576 | — | — | 1 | 4.92 |
| CHEMBL159685 | — | — | 1 | 4.89 |
| CHEMBL349619 | — | — | 1 | 4.85 |
| CHEMBL163183 | — | — | 1 | 4.85 |
| CHEMBL162017 | — | — | 1 | 4.80 |
| CHEMBL348361 | — | — | 1 | 4.80 |
| CHEMBL163103 | — | — | 1 | 4.72 |
| CHEMBL159599 | — | — | 1 | 4.57 |
| CHEMBL161329 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159826 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL356033 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL358165 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL159697 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL146303 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL148690 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL357489 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL160114 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL146268 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL159887 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL149175 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL349708 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL164268 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL346689 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL161784 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL159809 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL161374 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL348741 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL161012 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL353576 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL159685 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL349619 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL163183 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL159826 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL348361 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL162017 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL163103 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL159599 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL161329 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL347816 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL159395 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL159393 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL159946 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL160067 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL163926 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL159947 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL159544 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL348908 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL163921 | — | IC50 | = | 135000.0 | nM | - |