Assay Detail
Functional
CHEMBL703377
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Concentration required to inhibit 50% growth of L1210 cells in culture.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.08 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.41 |
| CHEMBL109229 | — | — | 1 | 8.35 |
| CHEMBL113799 | — | — | 1 | 7.92 |
| CHEMBL110251 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL109229 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL113799 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL110251 | — | IC50 | = | 23.9 | nM | 7.62 |