Assay Detail
Functional
CHEMBL703432
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Ability to inhibit L1210 murine leukemia tumor cell growth in culture after 48 hr of its exposure.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.70 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.34 |
| CHEMBL65620 | — | — | 1 | 7.75 |
| CHEMBL65711 | — | — | 1 | 7.54 |
| CHEMBL65616 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL65620 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65711 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL65616 | — | IC50 | = | 870.0 | nM | 6.06 |