Assay Detail
Functional
CHEMBL703438
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Antiproliferative activity was determined against murine leukemia cells (L1210)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.43 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450901 | — | — | 1 | 4.43 |
| CHEMBL444845 | — | — | 1 | - |
| CHEMBL62684 | — | — | 1 | - |
| CHEMBL465056 | — | — | 1 | - |
| CHEMBL87718 | — | — | 1 | - |
| CHEMBL85821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450901 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL444845 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL62684 | — | IC50 | > | 390000.0 | nM | - |
| CHEMBL465056 | — | IC50 | > | 770000.0 | nM | - |
| CHEMBL87718 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL85821 | — | IC50 | = | 670000.0 | nM | - |