Assay Detail
Functional
CHEMBL703445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to reduce Lewis lung carcinoma cell number to 50% of control cultures
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | LLTC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.64 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37656 | — | — | 1 | 8.28 |
| CHEMBL29602 | — | — | 1 | 8.25 |
| CHEMBL57636 | — | — | 1 | 8.21 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.92 |
| CHEMBL56830 | — | — | 1 | 7.77 |
| CHEMBL58041 | — | — | 1 | 7.70 |
| CHEMBL57085 | — | — | 1 | 7.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL293133 | — | — | 1 | 7.44 |
| CHEMBL292177 | — | — | 1 | 7.44 |
| CHEMBL57271 | — | — | 1 | 6.91 |
| CHEMBL57862 | — | — | 1 | 6.81 |
| CHEMBL60684 | — | — | 1 | 6.80 |
| CHEMBL57685 | — | — | 1 | 6.79 |
| CHEMBL60807 | — | — | 1 | 6.78 |
| CHEMBL56144 | — | — | 1 | 6.75 |
| CHEMBL9940 | — | — | 1 | 6.72 |
| CHEMBL56111 | — | — | 1 | 6.64 |
| CHEMBL291690 | — | — | 1 | 6.59 |
| CHEMBL294417 | — | — | 1 | 6.57 |
| CHEMBL417771 | — | — | 1 | 6.55 |
| CHEMBL57619 | — | — | 1 | 6.46 |
| CHEMBL418275 | — | — | 1 | 6.43 |
| CHEMBL292902 | — | — | 1 | 6.35 |
| CHEMBL291980 | — | — | 1 | 6.34 |
| CHEMBL57949 | — | — | 1 | 6.33 |
| CHEMBL56149 | — | — | 1 | 6.33 |
| CHEMBL293307 | — | — | 1 | 6.15 |
| CHEMBL57048 | — | — | 1 | 6.13 |
| CHEMBL60920 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37656 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL29602 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL57636 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL43 | AMSACRINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL56830 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL58041 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL57085 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL293133 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL292177 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL57271 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL57862 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL60684 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL57685 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL60807 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL56144 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL9940 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL56111 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL291690 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL294417 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL417771 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL57619 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL418275 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL292902 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL291980 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL57949 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL56149 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL293307 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL57048 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL60920 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL59374 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL61030 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL417223 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL60818 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL56174 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL57975 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL299679 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL57866 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL418116 | — | IC50 | = | 5950.0 | nM | 5.22 |