Assay Detail
Functional
CHEMBL703463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against rhinoviral 18 serotype in a plaque inhibition assay using monolayers of M-HeLa cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human rhinovirus sp. |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51194 | — | — | 1 | 5.23 |
| CHEMBL51721 | — | — | 1 | 5.18 |
| CHEMBL49452 | — | — | 1 | 5.17 |
| CHEMBL48926 | — | — | 1 | 5.12 |
| CHEMBL50299 | — | — | 1 | 5.09 |
| CHEMBL301581 | — | — | 1 | 5.05 |
| CHEMBL49821 | — | — | 1 | 5.05 |
| CHEMBL48312 | — | — | 1 | 5.00 |
| CHEMBL301387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51194 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL51721 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL49452 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL48926 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL50299 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL301581 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL49821 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL48312 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL301387 | — | IC50 | > | 8000.0 | nM | - |