Assay Detail
Functional
CHEMBL703467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against rhinoviral 2 serotype in a plaque inhibition assay using monolayers of M-HeLa cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human rhinovirus sp. |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.17 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301081 | — | — | 1 | 5.55 |
| CHEMBL48312 | — | — | 1 | 5.35 |
| CHEMBL50299 | — | — | 1 | 5.30 |
| CHEMBL49452 | — | — | 1 | 5.28 |
| CHEMBL48774 | — | — | 1 | 5.28 |
| CHEMBL283830 | — | — | 1 | 5.24 |
| CHEMBL299013 | — | — | 1 | 5.21 |
| CHEMBL51383 | — | — | 1 | 5.19 |
| CHEMBL301387 | — | — | 1 | 5.18 |
| CHEMBL302487 | — | — | 1 | 5.16 |
| CHEMBL48926 | — | — | 1 | 5.14 |
| CHEMBL298184 | — | — | 1 | 5.10 |
| CHEMBL51194 | — | — | 1 | 5.08 |
| CHEMBL49668 | — | — | 1 | 5.05 |
| CHEMBL48702 | — | — | 1 | 5.03 |
| CHEMBL301581 | — | — | 1 | 4.96 |
| CHEMBL300881 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301081 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL48312 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL50299 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL49452 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL48774 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL283830 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL299013 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL51383 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL301387 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL302487 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL48926 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL298184 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL51194 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL49668 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL48702 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL301581 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL300881 | — | IC50 | = | 15000.0 | nM | 4.82 |