Assay Detail
Functional
CHEMBL703515
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In vitro inhibitory concentration against Leishmania amazonensis promastigotes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.77 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069130 | — | — | 1 | 7.00 |
| CHEMBL2069129 | — | — | 1 | 5.96 |
| CHEMBL3138308 | — | — | 1 | 5.94 |
| CHEMBL3138393 | — | — | 1 | 5.92 |
| CHEMBL3138499 | — | — | 1 | 5.85 |
| CHEMBL3138314 | — | — | 1 | 5.76 |
| CHEMBL3137946 | — | — | 1 | 5.73 |
| CHEMBL3138264 | — | — | 1 | 5.49 |
| CHEMBL3138416 | — | — | 1 | 5.47 |
| CHEMBL3137954 | — | — | 1 | 5.37 |
| CHEMBL3138270 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069130 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2069129 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3138308 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3138393 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3138499 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3138314 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3137946 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL3138264 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3138416 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3137954 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL3138270 | — | IC50 | = | 10280.0 | nM | 4.99 |