Assay Detail
Functional
CHEMBL703518
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Inhibition of the growth of Lactobacillus casei
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Lacticaseibacillus casei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.70 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279302 | — | — | 1 | 6.27 |
| CHEMBL23278 | — | — | 1 | 5.77 |
| CHEMBL284013 | — | — | 1 | 5.66 |
| CHEMBL23699 | — | — | 1 | 5.42 |
| CHEMBL23872 | — | — | 1 | 5.40 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279302 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL23278 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL284013 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL23699 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL23872 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2e-05 | nM | - |