Assay Detail
Binding
CHEMBL703571
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The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic kainate (CHEMBL2109241) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Pyrrolylquinoxalinediones: Dicarboxylates as highly potent AMPA receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.47 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84142 | — | — | 1 | 6.16 |
| CHEMBL82375 | — | — | 1 | 5.92 |
| CHEMBL309831 | — | — | 1 | 5.44 |
| CHEMBL13260 | YM-90K | — | 1 | 5.32 |
| CHEMBL79454 | — | — | 1 | 5.30 |
| CHEMBL314248 | — | — | 1 | 5.24 |
| CHEMBL293613 | — | — | 1 | 5.23 |
| CHEMBL310503 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84142 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL82375 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL309831 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL13260 | YM-90K | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL79454 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL314248 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL293613 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL310503 | — | Ki | = | 6700.0 | nM | 5.17 |