Assay Detail
Functional
CHEMBL703607
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Tested for cell growth inhibition against L1210/CI920 cell line.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.83 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84163 | — | — | 1 | 5.85 |
| CHEMBL85436 | — | — | 1 | 5.55 |
| CHEMBL315076 | — | — | 1 | 5.50 |
| CHEMBL84904 | — | — | 1 | 5.30 |
| CHEMBL84728 | — | — | 1 | 4.92 |
| CHEMBL309415 | — | — | 1 | 4.80 |
| CHEMBL85871 | — | — | 1 | 4.75 |
| CHEMBL82181 | — | — | 1 | 4.64 |
| CHEMBL85848 | — | — | 1 | 4.62 |
| CHEMBL82261 | — | — | 1 | 4.61 |
| CHEMBL315627 | — | — | 1 | 4.37 |
| CHEMBL84935 | — | — | 1 | 4.35 |
| CHEMBL82390 | — | — | 1 | 4.24 |
| CHEMBL84605 | — | — | 1 | 4.16 |
| CHEMBL84045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84163 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL85436 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL315076 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL84904 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL84728 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL309415 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL85871 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL82181 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL85848 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL82261 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL315627 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL84935 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL82390 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL84605 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL84045 | — | IC50 | = | 250000.0 | nM | - |