Assay Detail
Functional
CHEMBL703613
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Cell growth inhibition against mouse leukemia L1210/R71 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.92 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346481 | — | — | 1 | 5.46 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 5.10 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 4.72 |
| CHEMBL422225 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346481 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL422225 | — | IC50 | = | 40000.0 | nM | 4.40 |