Assay Detail
Functional
CHEMBL703617
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Inhibitory concentration against growth of L1210/R81 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 ( R81) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.37 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27109 | — | — | 1 | 4.77 |
| CHEMBL441418 | — | — | 1 | 4.57 |
| CHEMBL280864 | — | — | 1 | 4.50 |
| CHEMBL18155 | — | — | 1 | 4.28 |
| CHEMBL416193 | — | — | 1 | 4.27 |
| CHEMBL423297 | — | — | 1 | 4.09 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 4.08 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL27821 | — | — | 1 | - |
| CHEMBL283702 | — | — | 1 | - |
| CHEMBL27514 | — | — | 1 | - |
| CHEMBL26534 | — | — | 1 | - |
| CHEMBL405237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27109 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL441418 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL280864 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL18155 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL416193 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL423297 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 200000.0 | nM | - |
| CHEMBL27821 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL283702 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL27514 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL26534 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL405237 | — | IC50 | > | 200000.0 | nM | - |