Assay Detail
Functional
CHEMBL703619
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Tested for cell-growth inhibition against mouse leukemic L1210/R81 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 ( R81) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.17 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26326 | — | — | 1 | 4.25 |
| CHEMBL27306 | — | — | 1 | 4.24 |
| CHEMBL283062 | — | — | 1 | 4.17 |
| CHEMBL25923 | — | — | 1 | 4.14 |
| CHEMBL28112 | — | — | 1 | 4.11 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 4.08 |
| CHEMBL26148 | — | — | 1 | - |
| CHEMBL434004 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL275229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26326 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL27306 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL283062 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL25923 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL28112 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL26148 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL434004 | — | IC50 | > | 218000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 197000.0 | nM | - |
| CHEMBL275229 | — | IC50 | = | 215000.0 | nM | - |