Assay Detail
Functional
CHEMBL703979
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Concentration of the Antiproliferative compound required for the 50% inhibition of Growth against K562 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.40 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311206 | — | — | 1 | 7.00 |
| CHEMBL410744 | — | — | 1 | 6.16 |
| CHEMBL2059157 | — | — | 1 | 5.82 |
| CHEMBL608195 | — | — | 1 | 5.82 |
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 5.52 |
| CHEMBL3144028 | — | — | 1 | 4.96 |
| CHEMBL3144029 | — | — | 1 | 4.75 |
| CHEMBL162782 | — | — | 1 | 4.37 |
| CHEMBL608194 | — | — | 1 | 4.22 |
| CHEMBL348359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311206 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL410744 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2059157 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL608195 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3144028 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3144029 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL162782 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL608194 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL348359 | — | IC50 | = | 2089700.0 | nM | - |