Assay Detail
Functional
CHEMBL703985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of peak K+ currents against Kv1.2 gene
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Potassium voltage-gated channel subfamily A member 2 (CHEMBL2086) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 4.59 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141680 | — | — | 1 | 4.75 |
| CHEMBL342911 | — | — | 1 | 4.64 |
| CHEMBL24171 | BERGAPTEN | 3.0 | 1 | 4.39 |
| CHEMBL141623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141680 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL342911 | — | Kd | = | 23000.0 | nM | 4.64 |
| CHEMBL24171 | BERGAPTEN | Kd | = | 41000.0 | nM | 4.39 |
| CHEMBL141623 | — | Kd | = | 590000.0 | nM | - |