Assay Detail
Functional
CHEMBL703988
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Inhibitory concentration against growth of L1210 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.58 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.12 |
| CHEMBL27109 | — | — | 1 | 9.05 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.70 |
| CHEMBL441418 | — | — | 1 | 8.49 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.34 |
| CHEMBL423297 | — | — | 1 | 7.77 |
| CHEMBL27514 | — | — | 1 | 7.70 |
| CHEMBL27821 | — | — | 1 | 7.50 |
| CHEMBL416193 | — | — | 1 | 7.43 |
| CHEMBL283702 | — | — | 1 | 6.70 |
| CHEMBL26534 | — | — | 1 | 6.39 |
| CHEMBL280864 | — | — | 1 | 5.89 |
| CHEMBL405237 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL27109 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL441418 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL423297 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL27514 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL27821 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL416193 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL283702 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL26534 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL280864 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL405237 | — | IC50 | = | 3200.0 | nM | 5.50 |