Assay Detail
Functional
CHEMBL704122
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Inhibitory activity against sensitive L1210 cell lines
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.49 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44207 | — | — | 1 | 10.40 |
| CHEMBL40515 | — | — | 1 | 9.70 |
| CHEMBL43809 | — | — | 1 | 9.43 |
| CHEMBL42100 | — | — | 1 | 8.59 |
| CHEMBL40586 | — | — | 1 | 8.54 |
| CHEMBL41290 | — | — | 1 | 8.27 |
| CHEMBL40716 | — | — | 1 | 8.27 |
| CHEMBL42201 | — | — | 1 | 8.22 |
| CHEMBL42571 | — | — | 1 | 8.22 |
| CHEMBL40359 | — | — | 1 | 8.17 |
| CHEMBL40865 | — | — | 1 | 8.10 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.01 |
| CHEMBL289120 | — | — | 1 | 7.77 |
| CHEMBL288699 | — | — | 1 | 7.64 |
| CHEMBL40776 | — | — | 1 | 7.47 |
| CHEMBL41450 | — | — | 1 | 7.46 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL40314 | — | — | 1 | 7.39 |
| CHEMBL40568 | — | — | 1 | 7.28 |
| CHEMBL40924 | — | — | 1 | 7.20 |
| CHEMBL42490 | — | — | 1 | 7.11 |
| CHEMBL288217 | — | — | 1 | 6.93 |
| CHEMBL416242 | — | — | 1 | 6.81 |
| CHEMBL43763 | — | — | 1 | 6.74 |
| CHEMBL40313 | — | — | 1 | 6.66 |
| CHEMBL43931 | — | — | 1 | 6.38 |
| CHEMBL287719 | — | — | 1 | 6.33 |
| CHEMBL41561 | — | — | 1 | 6.33 |
| CHEMBL290060 | — | — | 1 | 6.31 |
| CHEMBL289729 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44207 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL40515 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL43809 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL42100 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL40586 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL41290 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL40716 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL42201 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL42571 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL40359 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL40865 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL289120 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL288699 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL40776 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL41450 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL40314 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL40568 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL40924 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL42490 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL288217 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL416242 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL43763 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL40313 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL43931 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL287719 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL41561 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL290060 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL289729 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL43920 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL296224 | — | IC50 | = | 6250.0 | nM | 5.20 |