Assay Detail
Functional
CHEMBL704123
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Inhibitory activity for the growth inhibition of L1210 cell line.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.66 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.41 |
| CHEMBL113799 | — | — | 1 | 7.92 |
| CHEMBL110251 | — | — | 1 | 7.62 |
| CHEMBL162414 | — | — | 1 | 7.46 |
| CHEMBL162701 | — | — | 1 | 7.30 |
| CHEMBL279508 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3.92 | nM | 8.41 |
| CHEMBL113799 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL110251 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL162414 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL162701 | — | IC50 | = | 50.3 | nM | 7.30 |
| CHEMBL279508 | — | IC50 | = | 57.2 | nM | 7.24 |