Assay Detail
Functional
CHEMBL704235
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Compound was tested for the inhibition of L1210: 1565 cell growth in mouse.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.54 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55437 | — | — | 1 | 6.17 |
| CHEMBL61300 | — | — | 1 | 5.89 |
| CHEMBL58548 | — | — | 1 | 5.85 |
| CHEMBL293148 | — | — | 1 | 5.66 |
| CHEMBL412127 | — | — | 1 | 5.64 |
| CHEMBL434602 | — | — | 1 | 5.36 |
| CHEMBL299062 | — | — | 1 | 4.89 |
| CHEMBL301895 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55437 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL61300 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL58548 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL293148 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL412127 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL434602 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL299062 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL301895 | — | IC50 | = | 14000.0 | nM | 4.85 |