Assay Detail
Binding
CHEMBL704379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Leukotriene B4 receptor guinea pig lung membrane using [3H]LTB4 as radioligand
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.04 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292782 | — | — | 1 | 10.40 |
| CHEMBL340460 | — | — | 1 | 9.96 |
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 9.92 |
| CHEMBL136700 | — | — | 1 | 9.15 |
| CHEMBL88337 | — | — | 1 | 8.92 |
| CHEMBL336469 | — | — | 1 | 8.85 |
| CHEMBL139969 | — | — | 1 | 8.85 |
| CHEMBL342395 | — | — | 1 | 8.55 |
| CHEMBL167520 | — | — | 1 | 8.43 |
| CHEMBL141671 | — | — | 1 | 8.42 |
| CHEMBL129463 | — | — | 1 | 8.40 |
| CHEMBL435273 | — | — | 1 | 8.36 |
| CHEMBL138665 | — | — | 1 | 8.36 |
| CHEMBL353378 | — | — | 1 | 8.21 |
| CHEMBL141362 | — | — | 1 | 8.19 |
| CHEMBL329123 | ETALOCIB | 2.0 | 1 | 8.18 |
| CHEMBL136476 | — | — | 1 | 8.17 |
| CHEMBL341757 | — | — | 1 | 8.08 |
| CHEMBL139155 | — | — | 1 | 8.07 |
| CHEMBL138944 | — | — | 1 | 8.02 |
| CHEMBL139799 | — | — | 1 | 7.96 |
| CHEMBL138954 | — | — | 1 | 7.96 |
| CHEMBL139115 | — | — | 1 | 7.96 |
| CHEMBL139254 | — | — | 1 | 7.96 |
| CHEMBL129272 | — | — | 1 | 7.92 |
| CHEMBL336671 | — | — | 1 | 7.89 |
| CHEMBL423003 | — | — | 1 | 7.85 |
| CHEMBL138370 | — | — | 1 | 7.85 |
| CHEMBL336665 | — | — | 1 | 7.85 |
| CHEMBL138784 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292782 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL340460 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL65061 | LEUKOTRIENE_B4 | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL136700 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL88337 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL336469 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL139969 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL342395 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL167520 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL141671 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL129463 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL435273 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL138665 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL353378 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL141362 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL329123 | ETALOCIB | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL136476 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL341757 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL139155 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL138944 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL139799 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL138954 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL139115 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL139254 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL129272 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL336671 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL423003 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL138370 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL336665 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL138784 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL138532 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL14823 | SC-41390 | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL138193 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL138832 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL345037 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL138239 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL167923 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL167850 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL168011 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL407983 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL138819 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL167972 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL167261 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL424361 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL15766 | LY-255283 | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL167580 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL166862 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL336254 | — | Ki | = | 200.0 | nM | 6.70 |