Assay Detail
Functional
CHEMBL704554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect on the biosyntheses of RNA in murine L1210 cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.24 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158037 | — | — | 1 | 5.24 |
| CHEMBL348877 | — | — | 1 | - |
| CHEMBL151677 | — | — | 1 | - |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158037 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL348877 | — | IC50 | = | 276000.0 | nM | - |
| CHEMBL151677 | — | IC50 | = | 336000.0 | nM | - |
| CHEMBL852 | MELPHALAN | IC50 | > | 100000.0 | nM | - |