Assay Detail
Functional
CHEMBL704563
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Tested in vitro inhibitory activity against murine leukemia L1210
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.42 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.30 |
| CHEMBL1204346 | — | — | 1 | 6.28 |
| CHEMBL337389 | — | — | 1 | 5.24 |
| CHEMBL334601 | — | — | 1 | 4.91 |
| CHEMBL133973 | — | — | 1 | 4.60 |
| CHEMBL336799 | — | — | 1 | 4.16 |
| CHEMBL1790974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1204346 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL337389 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL334601 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL133973 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL336799 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL1790974 | — | IC50 | = | 261000.0 | nM | - |