Assay Detail
Functional
CHEMBL704565
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Tested for 50% inhibition of L1210 cell growth in vitro
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.29 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171480 | — | — | 1 | 6.40 |
| CHEMBL62769 | — | — | 1 | 5.62 |
| CHEMBL422395 | — | — | 1 | 5.52 |
| CHEMBL62672 | — | — | 1 | 5.40 |
| CHEMBL302669 | — | — | 1 | 5.39 |
| CHEMBL62599 | — | — | 1 | 5.37 |
| CHEMBL62675 | — | — | 1 | 5.23 |
| CHEMBL64215 | — | — | 1 | 5.16 |
| CHEMBL304407 | — | — | 1 | 4.93 |
| CHEMBL293442 | — | — | 1 | 4.60 |
| CHEMBL64776 | — | — | 1 | 4.58 |
| CHEMBL433059 | — | — | 1 | - |
| CHEMBL62419 | — | — | 1 | - |
| CHEMBL417562 | — | — | 1 | - |
| CHEMBL62697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171480 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL62769 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL422395 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL62672 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL302669 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL62599 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL62675 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL64215 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL304407 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL293442 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL64776 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL433059 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL62419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL417562 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL62697 | — | IC50 | > | 10000.0 | nM | - |