Assay Detail
Functional
CHEMBL704567
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In vitro cytotoxicity against L1210 (murine leukemia) cells.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.55 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351131 | — | — | 1 | 8.15 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 8.10 |
| CHEMBL347323 | THIOCORNIGERINE | — | 1 | 8.00 |
| CHEMBL346431 | — | — | 1 | 8.00 |
| CHEMBL152450 | — | — | 1 | 7.70 |
| CHEMBL19531 | — | — | 1 | 7.70 |
| CHEMBL277998 | — | — | 1 | 7.52 |
| CHEMBL152799 | — | — | 1 | 7.52 |
| CHEMBL348049 | — | — | 1 | 7.52 |
| CHEMBL356376 | — | — | 1 | 7.52 |
| CHEMBL155390 | — | — | 1 | 7.52 |
| CHEMBL29086 | — | — | 1 | 7.52 |
| CHEMBL153439 | — | — | 1 | 7.40 |
| CHEMBL351349 | — | — | 1 | 7.40 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.40 |
| CHEMBL298240 | — | — | 1 | 7.40 |
| CHEMBL152446 | — | — | 1 | 7.40 |
| CHEMBL154225 | — | — | 1 | 7.22 |
| CHEMBL438563 | — | — | 1 | 7.16 |
| CHEMBL152356 | — | — | 1 | 7.16 |
| CHEMBL346002 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351131 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL347323 | THIOCORNIGERINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL346431 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL152450 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19531 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL277998 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL152799 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL348049 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL356376 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL155390 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL29086 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL153439 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL351349 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL107 | COLCHICINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL298240 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL152446 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL154225 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL438563 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL152356 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL346002 | — | IC50 | = | 70.0 | nM | 7.16 |