Assay Detail
Functional
CHEMBL704569
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The compound was tested for its growth inhibitory activity against L1210 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.12 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112061 | — | — | 1 | 9.89 |
| CHEMBL114733 | — | — | 1 | 9.19 |
| CHEMBL114987 | — | — | 1 | 8.82 |
| CHEMBL422395 | — | — | 1 | 8.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112061 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL114733 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL114987 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL422395 | — | IC50 | = | 2.61 | nM | 8.58 |