Assay Detail
Functional
CHEMBL704649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity against human KB-VIN10 cell line overexpressing P-gp 170/MDR
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-VIN10 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.76 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.62 |
| CHEMBL330407 | — | — | 1 | 8.12 |
| CHEMBL9011 | — | — | 1 | 7.62 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.52 |
| CHEMBL99988 | — | — | 1 | 7.51 |
| CHEMBL329925 | — | — | 1 | 7.40 |
| CHEMBL99862 | — | — | 1 | 6.90 |
| CHEMBL8953 | — | — | 1 | 6.79 |
| CHEMBL101404 | — | — | 1 | 6.51 |
| CHEMBL330402 | — | — | 1 | 6.49 |
| CHEMBL9309 | — | — | 1 | 6.45 |
| CHEMBL99400 | — | — | 1 | 6.10 |
| CHEMBL99984 | — | — | 1 | 6.10 |
| CHEMBL99914 | — | — | 1 | 5.54 |
| CHEMBL99334 | — | — | 1 | 5.42 |
| CHEMBL97877 | — | — | 1 | 5.07 |
| CHEMBL98983 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL330407 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL9011 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99988 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL329925 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL99862 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL8953 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL101404 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL330402 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL9309 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL99400 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL99984 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL99914 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL99334 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL97877 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL98983 | — | IC50 | > | 10000.0 | nM | - |