Assay Detail
Functional
CHEMBL704660
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In vitro inhibitory activity against EGF-stimulated proliferation of KB2 cells in culture
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.67 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56802 | — | — | 1 | 7.30 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.10 |
| CHEMBL301018 | — | — | 1 | 7.10 |
| CHEMBL300791 | — | — | 1 | 7.05 |
| CHEMBL291514 | — | — | 1 | 6.92 |
| CHEMBL57759 | — | — | 1 | 6.92 |
| CHEMBL299672 | — | — | 1 | 6.92 |
| CHEMBL1788321 | — | — | 1 | 6.89 |
| CHEMBL56936 | — | — | 1 | 6.82 |
| CHEMBL57990 | — | — | 1 | 6.82 |
| CHEMBL1744086 | — | — | 1 | 6.80 |
| CHEMBL55425 | — | — | 1 | 6.80 |
| CHEMBL55424 | — | — | 1 | 6.80 |
| CHEMBL294395 | — | — | 1 | 6.77 |
| CHEMBL56912 | — | — | 1 | 6.75 |
| CHEMBL56142 | — | — | 1 | 6.72 |
| CHEMBL56266 | — | — | 1 | 6.66 |
| CHEMBL55794 | — | — | 1 | 6.66 |
| CHEMBL293064 | — | — | 1 | 6.51 |
| CHEMBL57892 | — | — | 1 | 6.50 |
| CHEMBL293090 | — | — | 1 | 6.46 |
| CHEMBL14699 | — | — | 1 | 6.42 |
| CHEMBL60826 | — | — | 1 | 6.42 |
| CHEMBL56502 | — | — | 1 | 6.41 |
| CHEMBL56505 | — | — | 1 | 6.34 |
| CHEMBL294034 | — | — | 1 | 6.19 |
| CHEMBL57758 | — | — | 1 | 6.14 |
| CHEMBL299893 | — | — | 1 | 6.07 |
| CHEMBL56027 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56802 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL939 | GEFITINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL301018 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL300791 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL291514 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL57759 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL299672 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1788321 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL56936 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL57990 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1744086 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL55425 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL55424 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL294395 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL56912 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL56142 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL56266 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL55794 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL293064 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL57892 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL293090 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL14699 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL60826 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL56502 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL56505 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL294034 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL57758 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL299893 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL56027 | — | IC50 | = | 910.0 | nM | 6.04 |