Assay Detail
Functional
CHEMBL704721
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The compound was tested in vitro for the inhibition of L1210 cell growth in culture
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.17 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307914 | — | — | 1 | 7.72 |
| CHEMBL73902 | — | — | 1 | 7.57 |
| CHEMBL169981 | — | — | 1 | 7.57 |
| CHEMBL420935 | — | — | 1 | 7.30 |
| CHEMBL307399 | — | — | 1 | 7.28 |
| CHEMBL75291 | — | — | 1 | 7.21 |
| CHEMBL419092 | — | — | 1 | 7.12 |
| CHEMBL434209 | — | — | 1 | 7.05 |
| CHEMBL40321 | — | — | 1 | 6.96 |
| CHEMBL77314 | — | — | 1 | 6.85 |
| CHEMBL73971 | — | — | 1 | 6.85 |
| CHEMBL420204 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307914 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL73902 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL169981 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL420935 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL307399 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL75291 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL419092 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL434209 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL40321 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL77314 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL73971 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL420204 | — | IC50 | = | 280.0 | nM | 6.55 |