Assay Detail
Functional
CHEMBL704752
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Inhibitory concentration of compound in growth of L-1210 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.02 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.21 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.57 |
| CHEMBL11187 | — | — | 1 | 7.39 |
| CHEMBL10592 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL11187 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL10592 | — | IC50 | = | 125.0 | nM | 6.90 |