Assay Detail
Functional
CHEMBL704755
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Inhibitory concentration against L1210 leukemia cell proliferation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.35 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93217 | — | — | 1 | 7.40 |
| CHEMBL93426 | — | — | 1 | 7.22 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.00 |
| CHEMBL327547 | — | — | 1 | 6.70 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.48 |
| CHEMBL327796 | — | — | 1 | 6.40 |
| CHEMBL327813 | — | — | 1 | 6.22 |
| CHEMBL93669 | — | — | 1 | 6.22 |
| CHEMBL92201 | — | — | 1 | 6.22 |
| CHEMBL316118 | — | — | 1 | 6.00 |
| CHEMBL94193 | — | — | 1 | 5.77 |
| CHEMBL93773 | — | — | 1 | 4.57 |
| CHEMBL93588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93217 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL93426 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL327547 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL327796 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL327813 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL93669 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL92201 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL316118 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL94193 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL93773 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL93588 | — | IC50 | > | 50000.0 | nM | - |