Assay Detail
Functional
CHEMBL704764
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Tested for in vitro cytostatic activity against murine leukemia L1210
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.73 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604208 | — | — | 1 | 5.92 |
| CHEMBL608056 | — | — | 1 | 4.82 |
| CHEMBL607764 | — | — | 1 | 4.60 |
| CHEMBL2092789 | — | — | 1 | 4.38 |
| CHEMBL206231 | — | — | 1 | 4.37 |
| CHEMBL608344 | — | — | 1 | 4.27 |
| CHEMBL2092790 | — | — | 1 | - |
| CHEMBL2092957 | — | — | 1 | - |
| CHEMBL610125 | — | — | 1 | - |
| CHEMBL2092958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604208 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL608056 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL607764 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2092789 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL206231 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL608344 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2092790 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL2092957 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL610125 | — | IC50 | = | 301000.0 | nM | - |
| CHEMBL2092958 | — | IC50 | = | 104000.0 | nM | - |