Assay Detail
Functional
CHEMBL704810
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Concentration to inhibit cell growth was measured on L1210:1565 cell line
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.57 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264095 | — | — | 1 | 7.05 |
| CHEMBL268453 | — | — | 1 | 6.75 |
| CHEMBL266066 | — | — | 1 | 6.62 |
| CHEMBL6325 | — | — | 1 | 6.40 |
| CHEMBL6496 | — | — | 1 | 6.40 |
| CHEMBL268100 | — | — | 1 | 6.30 |
| CHEMBL268151 | — | — | 1 | 6.30 |
| CHEMBL6632 | — | — | 1 | 6.28 |
| CHEMBL6271 | — | — | 1 | 5.90 |
| CHEMBL269600 | — | — | 1 | 5.80 |
| CHEMBL6715 | — | — | 1 | 5.54 |
| CHEMBL269342 | — | — | 1 | 5.32 |
| CHEMBL267702 | — | — | 1 | 5.30 |
| CHEMBL6357 | — | — | 1 | 5.30 |
| CHEMBL6436 | — | — | 1 | 5.28 |
| CHEMBL414012 | — | — | 1 | 5.23 |
| CHEMBL266065 | — | — | 1 | 5.12 |
| CHEMBL6676 | — | — | 1 | 5.09 |
| CHEMBL6636 | — | — | 1 | 4.89 |
| CHEMBL6663 | — | — | 1 | 4.85 |
| CHEMBL267832 | — | — | 1 | 4.64 |
| CHEMBL266956 | — | — | 1 | 4.52 |
| CHEMBL6788 | — | — | 1 | 4.47 |
| CHEMBL266509 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264095 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL268453 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL266066 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL6325 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL6496 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL268100 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL268151 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL6632 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL6271 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL269600 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL6715 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL269342 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL267702 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6357 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6436 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL414012 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL266065 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL6676 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL6636 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL6663 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL267832 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL266956 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL6788 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL266509 | — | IC50 | = | 40000.0 | nM | 4.40 |