Assay Detail
Functional
CHEMBL704812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against L1210:1565 cell growth.
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.93 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355543 | — | — | 2 | 5.34 |
| CHEMBL170933 | — | — | 2 | 5.17 |
| CHEMBL354785 | — | — | 1 | 5.11 |
| CHEMBL353066 | — | — | 1 | 5.11 |
| CHEMBL349432 | — | — | 2 | 5.09 |
| CHEMBL170789 | — | — | 1 | 4.82 |
| CHEMBL263325 | — | — | 1 | 4.68 |
| CHEMBL168970 | — | — | 1 | 4.57 |
| CHEMBL168553 | — | — | 1 | 4.00 |
| CHEMBL352357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355543 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL355543 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL170933 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL354785 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL353066 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL349432 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL170933 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL349432 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL170789 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL263325 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL168970 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL168553 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL352357 | — | IC50 | > | 10000.0 | nM | - |