Assay Detail
Functional
CHEMBL704813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relative resistance was measured in L1210:1565 cell line
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.69 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268100 | — | — | 1 | 6.48 |
| CHEMBL6496 | — | — | 1 | 6.44 |
| CHEMBL6325 | — | — | 1 | 6.43 |
| CHEMBL264095 | — | — | 1 | 6.42 |
| CHEMBL266066 | — | — | 1 | 6.41 |
| CHEMBL6271 | — | — | 1 | 6.29 |
| CHEMBL269342 | — | — | 1 | 6.22 |
| CHEMBL268151 | — | — | 1 | 6.12 |
| CHEMBL267702 | — | — | 1 | 6.08 |
| CHEMBL6632 | — | — | 1 | 6.08 |
| CHEMBL268453 | — | — | 1 | 6.07 |
| CHEMBL269600 | — | — | 1 | 6.04 |
| CHEMBL6357 | — | — | 1 | 5.89 |
| CHEMBL6636 | — | — | 1 | 5.85 |
| CHEMBL6715 | — | — | 1 | 5.77 |
| CHEMBL266956 | — | — | 1 | 5.70 |
| CHEMBL266065 | — | — | 1 | 5.38 |
| CHEMBL6436 | — | — | 1 | 5.22 |
| CHEMBL6663 | — | — | 1 | 5.16 |
| CHEMBL6788 | — | — | 1 | 4.85 |
| CHEMBL266509 | — | — | 1 | 4.75 |
| CHEMBL267832 | — | — | 1 | 4.64 |
| CHEMBL414012 | — | — | 1 | 4.13 |
| CHEMBL6676 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268100 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL6496 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL6325 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL264095 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL266066 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL6271 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL269342 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL268151 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL267702 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL6632 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL268453 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL269600 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL6357 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL6636 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL6715 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL266956 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL266065 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL6436 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL6663 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL6788 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL266509 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL267832 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL414012 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL6676 | — | IC50 | = | 96000.0 | nM | 4.02 |