Assay Detail
Functional
CHEMBL704814
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Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.50 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337914 | — | — | 1 | 6.12 |
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 6.12 |
| CHEMBL126555 | — | — | 1 | 6.10 |
| CHEMBL338429 | — | — | 1 | 6.03 |
| CHEMBL420155 | — | — | 1 | 5.89 |
| CHEMBL126648 | PLEVITREXED | 2.0 | 1 | 5.89 |
| CHEMBL105346 | — | — | 1 | 5.89 |
| CHEMBL126325 | — | — | 1 | 5.75 |
| CHEMBL127583 | — | — | 1 | 5.70 |
| CHEMBL126914 | — | — | 1 | 5.62 |
| CHEMBL439975 | — | — | 1 | 5.57 |
| CHEMBL127142 | — | — | 1 | 5.52 |
| CHEMBL127954 | — | — | 1 | 5.51 |
| CHEMBL340814 | — | — | 1 | 5.51 |
| CHEMBL127598 | — | — | 1 | 5.48 |
| CHEMBL338644 | — | — | 1 | 5.42 |
| CHEMBL127541 | — | — | 1 | 5.36 |
| CHEMBL340888 | — | — | 1 | 5.32 |
| CHEMBL441086 | — | — | 1 | 5.30 |
| CHEMBL125856 | — | — | 1 | 5.28 |
| CHEMBL341323 | — | — | 1 | 5.28 |
| CHEMBL389051 | — | — | 1 | 5.26 |
| CHEMBL338598 | — | — | 1 | 5.25 |
| CHEMBL128033 | — | — | 1 | 5.23 |
| CHEMBL340842 | — | — | 1 | 5.18 |
| CHEMBL434209 | — | — | 1 | 5.09 |
| CHEMBL127745 | — | — | 1 | 5.07 |
| CHEMBL341334 | — | — | 1 | 5.00 |
| CHEMBL125971 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337914 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL225071 | RALTITREXED | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL126555 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL338429 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL420155 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL126648 | PLEVITREXED | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL105346 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL126325 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL127583 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126914 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL439975 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL127142 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL127954 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL340814 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL127598 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL338644 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL127541 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL340888 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL441086 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL125856 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL341323 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL389051 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL338598 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL128033 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL340842 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL434209 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL127745 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL341334 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL125971 | — | IC50 | = | 23000.0 | nM | 4.64 |