Assay Detail
Functional
CHEMBL704816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the concentration to inhibit 50% of L1210:1565 cell growth.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.55 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 6.02 |
| CHEMBL71366 | — | — | 1 | 5.68 |
| CHEMBL40321 | — | — | 1 | 5.38 |
| CHEMBL74064 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL71366 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL40321 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL74064 | — | IC50 | = | 7700.0 | nM | 5.11 |