Assay Detail
Functional
CHEMBL704817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against L1210:RD1694 cell growth
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (RD1694) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.76 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168970 | — | — | 1 | 6.36 |
| CHEMBL170789 | — | — | 1 | 6.17 |
| CHEMBL170975 | — | — | 1 | 6.06 |
| CHEMBL355543 | — | — | 2 | 5.57 |
| CHEMBL170494 | — | — | 1 | 5.54 |
| CHEMBL352327 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168970 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL170789 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL170975 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL355543 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL355543 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL170494 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL352327 | — | IC50 | = | 8900.0 | nM | 5.05 |