Assay Detail
Functional
CHEMBL704819
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Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (RD1694) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.11 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126648 | PLEVITREXED | 2.0 | 1 | 7.12 |
| CHEMBL127954 | — | — | 1 | 6.85 |
| CHEMBL126325 | — | — | 1 | 6.62 |
| CHEMBL439975 | — | — | 1 | 6.51 |
| CHEMBL127541 | — | — | 1 | 6.50 |
| CHEMBL338598 | — | — | 1 | 6.41 |
| CHEMBL128033 | — | — | 1 | 6.37 |
| CHEMBL340888 | — | — | 1 | 6.35 |
| CHEMBL127142 | — | — | 1 | 6.22 |
| CHEMBL341334 | — | — | 1 | 6.03 |
| CHEMBL434209 | — | — | 1 | 5.57 |
| CHEMBL389051 | — | — | 1 | 4.89 |
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126648 | PLEVITREXED | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL127954 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL126325 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL439975 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL127541 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL338598 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL128033 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL340888 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL127142 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL341334 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL434209 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL389051 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL225071 | RALTITREXED | IC50 | = | 95000.0 | nM | 4.02 |