Assay Detail
Functional
CHEMBL704846
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Cytotoxicity in KB cells.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609505 | — | — | 1 | 5.92 |
| CHEMBL611857 | — | — | 1 | 5.21 |
| CHEMBL3143585 | — | — | 1 | 5.17 |
| CHEMBL355388 | — | — | 1 | 5.00 |
| CHEMBL2092812 | — | — | 1 | 4.82 |
| CHEMBL167265 | — | — | 1 | - |
| CHEMBL165139 | — | — | 1 | - |
| CHEMBL2093055 | — | — | 1 | - |
| CHEMBL3143586 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL166984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609505 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL611857 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3143585 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL355388 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2092812 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL167265 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2093055 | — | IC50 | < | 1200.0 | nM | - |
| CHEMBL3143586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL166984 | — | IC50 | > | 100000.0 | nM | - |