Assay Detail
Functional
CHEMBL704851
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Growth inhibitory activity (antiproliferative) against KB cell lines
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.08 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283631 | — | — | 1 | 7.50 |
| CHEMBL30990 | — | — | 1 | 6.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.79 |
| CHEMBL32073 | — | — | 1 | 6.38 |
| CHEMBL31444 | — | — | 1 | 6.32 |
| CHEMBL30757 | — | — | 1 | 5.18 |
| CHEMBL30287 | — | — | 1 | 4.88 |
| CHEMBL31794 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283631 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL30990 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL32073 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL31444 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL30757 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL30287 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL31794 | — | IC50 | = | 23420.0 | nM | 4.63 |