Assay Detail
Functional
CHEMBL704856
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In vitro cytotoxicity against Plasmodium falciparum infected KB cell line
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.19 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346963 | — | — | 1 | 6.00 |
| CHEMBL352441 | — | — | 1 | 5.80 |
| CHEMBL21921 | — | — | 1 | 5.80 |
| CHEMBL161117 | — | — | 1 | 5.40 |
| CHEMBL161451 | — | — | 1 | 5.40 |
| CHEMBL161009 | — | — | 1 | 5.40 |
| CHEMBL352195 | — | — | 1 | 5.40 |
| CHEMBL7130 | — | — | 1 | 5.40 |
| CHEMBL161757 | — | — | 1 | 5.22 |
| CHEMBL348151 | — | — | 1 | 5.22 |
| CHEMBL346982 | — | — | 1 | 5.22 |
| CHEMBL22403 | — | — | 1 | 5.19 |
| CHEMBL161034 | — | — | 1 | 5.16 |
| CHEMBL158570 | — | — | 1 | 5.16 |
| CHEMBL159052 | — | — | 1 | 5.16 |
| CHEMBL354011 | — | — | 1 | 5.10 |
| CHEMBL346932 | — | — | 1 | 5.08 |
| CHEMBL422005 | — | — | 1 | 5.00 |
| CHEMBL278813 | — | — | 1 | 4.82 |
| CHEMBL444605 | — | — | 1 | 4.77 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 4.39 |
| CHEMBL329687 | — | — | 1 | 4.06 |
| CHEMBL416552 | — | — | 1 | - |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
| CHEMBL22693 | — | — | 1 | - |
| CHEMBL158639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346963 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL352441 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL21921 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL161117 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161451 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161009 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL352195 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL7130 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161757 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL348151 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL346982 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL22403 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL161034 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL158570 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL159052 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL354011 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL346932 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL422005 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL278813 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL444605 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL747 | CYCLOGUANIL | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL329687 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL416552 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 109000.0 | nM | - |
| CHEMBL22693 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL158639 | — | IC50 | = | 110000.0 | nM | - |